Collection: Biochemicals & Inhibitors

Dissolve the compound in fresh, moisture-free DMSO, aliquot to single-use volumes, and store at -20°C or -80°C — most vendors consider stocks reliable for about three months. Aliquoting matters because DMSO is hygroscopic; repeated opening lets in water that can degrade the compound or crash it out of solution.

Vortex first, then sonicate; if needed, warm gently to no more than 50°C to avoid degrading the compound. If it still fails, the DMSO may have absorbed moisture — retry with a fresh anhydrous bottle, or check the datasheet for an alternative solvent recommendation.

The published IC50 usually comes from a cell-free enzyme assay, so cellular potency can differ substantially — titrate a concentration range in your own system rather than pipetting the IC50 directly. Dilute stepwise from the DMSO stock to avoid precipitation, and keep final DMSO below 0.3% to prevent vehicle toxicity.

Many are used in vivo, but formulation is the hard part — DMSO-heavy vehicles are rarely acceptable, so co-solvent systems such as PEG or cyclodextrin preparations are typically required. Check solubility data before planning dosing, and remember these are research-use-only compounds, not pharmaceutical grade.

The TriBioScience biochemical catalog — over 1,500 inhibitors plus common reagents such as BSA solutions and Krebs-Ringer buffers — reaches Israeli labs through Danyel Biotech, with local logistics and responsive quoting.