PITSTOP2, Clathrin-mediated endocystosis inhibitor

Product Details

Formal Name: N-[(5Z)-5-[(4-Bromophenyl)methylidene]-4-oxo-1,3-thiazolidin-2-ylidene]naphthalene-1-sulfonamide

Molecular Formula: C₂₀H₁₃BrN₂O₃S₂

Formula Weight: 473.4

CAS Number: 1332879-52-3

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 30 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Clathrin-mediated endocystosis inhibitor

Functions

PITSTOP2 inhibits clathrin-mediated endocytosis via blockade of endocytic ligand association with the clathrin terminal domain leading to clathrin coat assembly inhibition. It was able to cause a collapse of the nucleocytoplasmic permeability barrier and a reduction of Importin-ß binding. PITSTOP2 reduced viability in HeLa cells by trapping dividing cells in metaphase through loss of mitotic spindle integrity.

Application Procedures

First dissolved in DMSO (30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)