IDE2, Inducer of definitive endoderm

Product Details

Formal Name: 7-(2-Cyclopentylidenehydrazinyl)-7-oxoheptanoic acid

Alternate Names: 6-(N’-Cyclopenylidenehydrazinecarbonyl)hexanoic acid

Molecular Formula: C₁₂H₂₀N₂O₃

Formula Weight: 240.3

CAS Number: 1136466-93-7

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Inducer of definitive endoderm

Functions

Induces robust differentiation of embryonic stem cells into endoderm (EC₅₀ = 223 nM) in both mouse and human cells via activation of the TGFß signaling pathway. It was able to induce definitive endoderm in mouse embryonic stem cells in a protocol to create lung alveolar epithelial cells.

Application Procedures

First dissolved in DMSO (25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)