Vacuolin-1, PIKfyve inhibitor

Product Details

Formal Name: 3-Iodobenzaldehyde,2-[4-(diphenylamino)-6-(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazone

Molecular Formula: C₂₆H₂₄IN₇O

Formula Weight: 577.4

CAS Number: 351986-85-1

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (35 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

PIKfyve inhibitor

Functions

Vacuolin-1 inhibits autophagy via inhibition of Ca²⁺-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content and has no effect on other membrane-bound organelles. It has been shown to block endosome maturation by activating RAB5 which compromises the biogenesis and function of lysosomes including autophagosomal-lysosomal fusion and endosomal-lysosomal degradation. It potently inhibits migration, invasion and colony formation of cancer cells (which is linked to endosomal trafficking) and targets capping protein Zβ (CapZβ) in these processes. Inhibition of lysosomal maturation was shown to be due to potent inhibition of PIKfyve.

Application Procedures

First dissolved in DMSO (35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)