Dynarrestin, Cytoplasmic dynein 1/2 inhibitor

Product Details

Formal Name: Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiozole-5-carboxylate

Alternate Names: LDC3

Molecular Formula: C₂₂H₂₃F₂N₃O₂S

Formula Weight: 431.5

CAS Number: 2222768-84-3

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 40 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Cytoplasmic dynein 1/2 inhibitor

Functions

Dynarrestin is a reversible inhibitor of cytoplasmic dyneins 1 and 2. It inhibits dynein 1-dependent microtubule binding and motility without affecting ATP hydrolysis as well as dynein 2-dependent intraflagellar transport of the cargo IFT88 and flux of Smoothened within cilia without interfering with ciliogenesis.  Dynarrestin suppresses hedgehog-dependent proliferation of neuronal precursors and tumor cells. It binds protein tyrosine phosphatase interacting protein 51 (PTPIP51) leading to increased MAPK activation and complete blockade of Akt signaling in Her2 positive breast cancer cells (SKBR3).

Application Procedures

First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)