Collection: Stem Cell & Epigenetics

The cells grow on a defined coating instead of a layer of feeder fibroblasts, removing undefined animal components and simplifying passaging. The Cellartis DEF-CS 500 system takes this further with a defined medium and matrix that keep human iPS cells in a uniform 2D monolayer while preserving pluripotency and a normal karyotype.

Yes, in systems designed for it. DEF-CS supports single-cell seeding and harvesting, which gives precise control of density, enables clonal expansion after gene editing, and yields more homogeneous cultures than clump passaging — one of the most common questions in Takara Bio's DEF-CS FAQ and protocols.

Directed-differentiation systems walk pluripotent cells stepwise down a chosen lineage; Takara Bio's Cellartis range includes a complete iPS-cell-to-hepatocyte differentiation system for liver models, drug metabolism, and toxicity studies. Outcome still depends heavily on the quality and pluripotency of the starting line.

EpiXplore kits capture methylated genomic DNA through the methyl-CpG binding domain of MBD2 on magnetic beads — no antibodies, no bisulfite conversion — and elute fractions by methylation density. The Meth-Seq version feeds those fractions directly into Illumina-compatible library prep for epigenome sequencing.

Through Danyel Biotech, which distributes Takara Bio officially in Israel and keeps the stem cell and epigenetics range close to local delivery, with scientists on staff to advise on culture-system transitions. A quote request from this page reaches them directly.