XIB4035, GFRa1 agonist

Product Details

Formal Name: (E)-N4-(7-chloro-2-(2-chlorostyryl)quinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine, 3(H3PO4)

Molecular Formula: C₂₆H₃₁Cl₂N₃ · 3(H₃PO₄)

Formula Weight: 750.45

CAS Number: 10023-54-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml with warming).

Storage: RT

Stability: ≥ 2 years.

Applications

GFRa1 agonist

Functions

A novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor α-1 GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50=10.4 μM. Like GDNF, it induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells. Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease. GDNF agonists may be a new class of Parkinson’s disease therapeutics.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)