WS6, Stimulates pancreatic beta-cell proliferation

Product Details

Formal Name: 4-[[6-[Cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzeneacetamide

Molecular Formula: C₂₉H₃₁F₃N₆O₃

Formula Weight: 568.60

CAS Number: 1421227-53-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (30 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Stimulates pancreatic beta-cell proliferation

Functions

Stimulates human β-cell proliferation both in a dispersed islet proliferation assay and in intact human cultures. It has been shown to induce both α- and β-cell proliferation. May lead to the development of new therapeutics for diabetes. Induces adult hippocampal neurogenesis correlating with its antidepressant effect in a rat model of chronic unpredictable mild stress-induced depression. Has been used together with TTNPB and azakenpaullone, as a defined chemical cocktail to induce mouse totipotent stem cells. Cell permeable.

Application Procedures

First dissolved in DMSO (30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)