WHI-P131, JAK3 inhibitor

Product Details

Formal Name: 4-[(4’-hydroxyphenyl)amino]-6,7-dimehtoxyquinazoline

Alternate Names: JANEX-1

Molecular Formula: C₁₆H₁₅N₃O₃ · HCl

Formula Weight: 333.78

CAS Number: 202475-60-3

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 50 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

JAK3 inhibitor

Functions

JAK3 inhibitor. Inhibits human glioblastoma cell adhesion and invasion. Increases survival in a mouse ALS model. Delays or prevents autoimmune type 1 diabetes in NOD mice. Exhibits potent anti-inflammatory activity in mouse models of peritonitis, colitis, cellulitis and systemic inflammatory response syndrome. Displays protective effects against myocardial ischemia and reperfusion injury in mouse models.

Application Procedures

First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)