VU0134992, Kir4.1 blocker

Product Details

Formal Name: 2-(2-Bromo-4-propan-2-yl)phenoxy)-N-(2,2,6,6-tetramethlpiperidin-4-yl)acetamide

Molecular Formula: C₂₀H₃₁BrN₂O₂

Formula Weight: 411.4

CAS Number: 755002-90-5

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Kir4.1 blocker

Functions

Blocker of the inward rectifier potassium channel K_ir4.1 (IC₅₀ = 970 nM). It also inhibits K_ir3.1/3.2, K_ir3.1/3.4, and K_ir4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats suggesting therapeutic blood pressure lowering potential.  It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue.

Application Procedures

First dissolved in DMSO (25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)