TH257, Allosteric LIM kinase inhibitor

Product Details

Formal Name: N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide

Molecular Formula: C₂₄H₂₆N₂O₃S

Formula Weight: 422.5

CAS Number: 2244678-29-1

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 25 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Allosteric LIM kinase inhibitor

Functions

Potent (IC₅₀’s = 238 nM (LIMK1) and 91 nM (LIMK2)) and highly selective (no off-targets against 468 kinases) allosteric inhibitor of LIM kinase 1/2. It inhibited neurite outgrowth in N1E-115 cells in a dose-dependent manner.

Application Procedures

First dissolved in DMSO (25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)