Repaglinide, Kir6 blocker

Product Details

Formal Name: 2-Ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-oxoethyl]benzoic acid

Molecular Formula: C₂₇H₃₆N₂O₄

Formula Weight: 452.6

CAS Number: 135062-02-1

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Kir6 blocker

Functions

Blocker of the ATP-sensitive potassium channel Kir6 with hypoglycemic activity. Clinically useful antidiabetic agent. It displays 30-fold selectivity for pancreatic Kir6.2/SUR1 over cardiac Kir6.1/SUR2B and Kir6/SUR2A channels. Repaglinide displayed neuroprotective effects in Huntington disease, Parkinson’s disease, and ALS via blockade of the DREAM-ATF6 interaction.

Application Procedures

First dissolved in DMSO (25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored under an inert atmosphere at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)