Description
Interleukin-10 (IL-10) is an anti-inflammatory cytokine predominantly produced by monocytes and, to a lesser extent, by lymphocytes. It plays a crucial role in inducing regulatory T cells (Tregs) in vitro and is characteristically associated with CD4+ Treg lymphocytes. IL-10 inhibits the proliferation of CD4+ T cells, including Th1 and Th2 subsets, and suppresses the cytotoxic functions of cytotoxic T lymphocytes. Beyond monocytes and lymphocytes, IL-10 is produced by various cell types, such as T-cells, macrophages, and mast cells.
Product Details
Alternative names: cytokine synthesis inhibitory factor; CSIF; GVHDS; IL-10; IL10A; T-cell growth inhibitory factor; TGIF; Interleukin-10
Molecular Weight: 18.78 kDa
Formulation: Lyophilized from sterile PBS, pH 7.4.
Concentration: 0.5mg/mL
Purity: > 95% by SDS-PAGE
Application: SDS-PAGE
Storage Condition: Store at -20°C to -80°C for up to 12 months. Avoid repeated freeze-thaw cycles.
Research use only.
Documents
References
1. Somani, S., Menta, L., Wang-Johanning, F., Johanning, G., Hong, S., & Njoo, E. (2025, April 03). Synthesis, anticancer properties, and biological profiling of synthetic glycan analogs of proscillaridin A. bioRxiv. https://doi.org/10.1101/2025.03.31.646140
2. Somani, S., Menta, L., Wang-Johanning, F., Johanning, G., Hong, S., & Njoo, E. (2025, October 27). Synthesis, anticancer properties, and biological profiling of synthetic glycan analogs of proscillaridin A. Discover Pharmaceutical Sciences. 1, 25 (2025). https://doi.org/10.1007/s44395-025-00025-1
3. Gutti, M., Tsui, M., Yang, S., Xi, S., Luo, J., Desarkar, A., Xie, Y., Feng, M., Avadhani, U., Raghavan, S., Brierley-Green, E., Yu, E., & Njoo, E. (2025). Synthetic Derivatives of Vinpocetine as Antiproliferative Agents. Drugs and Drug Candidates, 4(4), 53. https://doi.org/10.3390/ddc4040053
Research use only.
