Anti-Sm Alegria Monotest

Anti-Sm is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgG antibodies against Sm proteins in human serum or plasma.

Sm proteins are extractable nuclear antigens (ENA). Detection of autoantibodies against these proteins is one of the ACR criteria for the diagnosis of systemic lupus erythematosus (SLE).

The detection of autoantibodies against Sm proteins is one of the ACR criteria for the diagnosis of systemic lupus erythematosus (SLE).

Because of the very high specificity (99 %) of this marker for SLE, the reliable detection of Sm autoantibodies suffices as a diagnostic criterion for the disease when fewer than three clinical ACR criteria have been met. However, a negative result does not rule out SLE.

The detection of Sm antibodies serves as a prognostic marker for SLE. Obviously, there is a relationship between the appearance of Sm antibodies and severe organ manifestations of the disease.

Format: Alegria® Monotest strips for the fully automated Alegria® / Alegria® 2 analyzers.

Specifications

Also available as Alegria Monotest (ORG 206, ORG 238); ELISA Kit (ORG 506, ORG 510, ORG 514).

Documents

• Instruction for Use
• Safety Data Sheet

Instruction for Use Revision 6. Earlier versions and additional languages can be found in the document archive.

Ordering Information