Anti-Centromere B ELISA Kit

Anti-Centromere B is an ELISA test system for the quantitative determination of IgG antibodies against centromere B in human serum or plasma.

The detection of autoantibodies against centromere protein B is of great diagnostic and prognostic importance in cases of progressive systemic scleroderma (PSS).

Centromere protein B is a DNA-associated protein. Together with other proteins, it forms the kinetochores of the chromosomes. Centromere B is the target antigen in over 95 % of patients with scleroderma or Raynaud’s phenomenon. Because autoantibodies against centromere proteins sometimes appear years before the disease appears, detection of anti-centromere B can be a significant indicator for the onset of scleroderma.

CREST syndrome, a limited and localized form of scleroderma with a more favourable prognosis can be serologically detected at an early stage with use of the ORGENTEC Anti-Centromere B test.

Format: ELISA kit, 96-well microplate format.

Specifications

Also available as Alegria Monotest (ORG 200, ORG 233, ORG 238); ELISA Kit (ORG 538, ORG 539, ORG 600).

Documents

• Instruction for Use
• Safety Data Sheet

Instruction for Use Revision 4. Earlier versions and additional languages can be found in the document archive.

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