Nintedanib, VEGFR, PDGFR and FGFR kinase inhibitor

Product Details

Formal Name: (3Z)-2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]-amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid, methyl ester

Alternate Names: BIBF-1120

Molecular Formula: C₃₁H₃₃N₅O₄

Formula Weight: 539.6

CAS Number: 656247-17-5

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 4 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

VEGFR, PDGFR and FGFR kinase inhibitor

Functions

A potent inhibitor of VEGFR, PDGFR, FGFR (IC₅₀ = 13-34 nM for VEGFR, 59-65 nM for PDGFR and 37-108 nM for FGFR subtypes). Also inhibits Flt-3, Lck, Lyn and Src (IC₅₀ = 16-156 nM). Inhibits VEGF-stimulated proliferation of HUVECs. Inhibits tumor growth in a mouse tumor xenograft model. A novel therapeutic agent for treatment of idiopathic pulmonary fibrosis. Alleviates chronic pancreatitis by inhibiting the activation of pancreatic stellate cells.

Application Procedures

First dissolved in DMSO (4 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)