MLS-544460, Eya2 phosphatase inhibitor

Product Details

Formal Name: 3-Fluoro-N-((E)-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino)benzamide

Alternate Names: MLS000544460

Molecular Formula: C₁₇H₁₂FN₃O₂S

Formula Weight: 341.4

CAS Number: 352336-36-8

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (40 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Eya2 phosphatase inhibitor

Functions

MLS-544460 is an allosteric inhibitor of the Eya2 tyrosine phosphatase (IC₅₀=4.1 µM) which is ineffective against other tyrosine phosphatases including Eya3 and PTP1B. Treatment of patient-derived glioma stem cells induced loss of bipolar spindle formation along with G2/M cell cycle arrest. GSC proliferation was inhibited at concentrations 4 to 10-fold lower than normal brain cells.  Treatment of Axolotls following amputation impairs limb regeneration indicating a role for Eya2 in vertebrate regeneration.

Application Procedures

First dissolved in DMSO (40 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)