The ÄKTA™ avant chromatography system is a preparative chromatography system designed for fast and secure development of scalable purification processes.
- Process development efficiency: Screen many experimental conditions unattended. Automate column packing, multi-step purifications, and buffer preparation.
- Trust in data: Get consistent performance across labs and users via the out-of-the box setup.
- Security: Protect your samples and columns, optimize your column use, and minimize downtime.
- Smooth tech transfer: Your process developed on an ÄKTA™ avant system is ready for the next step.
- Streamlined digital modeling: Rely on ÄKTA™ avant system for your DoE and mechanistic modeling workflows.
Data file | User manual | Compare lab ÄKTA™ systems
System components
The figure below shows the main components of the ÄKTA™ avant system. You can configure and customize your ÄKTA™ avant system by adding optional components.
Available in two versions
To accommodate different flow rate/pressure specifications. The versions have the same hardware setup.
| System |
ÄKTA™ avant 25 system |
ÄKTA™ avant 150 system |
| Maximum flow rate |
25 mL/min |
150 mL/min |
| Maximum pressure |
20 MPa |
5 MPa |
| Designed for |
- Resin screening and method optimization
- Working with many samples and conditions
|
- Scaling up and robustness testing
- Intelligent packing of AxiChrom™ 50 columns
|
| Optimized for |
Smaller columns (such as HiTrap™, HiScreen™, and Tricorn™ columns) |
Larger columns (such as HiScale™ and AxiChrom™ columns) |
Note: ÄKTA™ avant systems are not designed for use in GMP-regulated applications.
Typical process development tasks that you can perform with ÄKTA™ avant system:
- Screening chromatography resins
- Optimizing purification methods
- Intelligent column packing using preprogrammed methods
- Performing initial scale up
- Producing pure target molecules for use in preclinical studies (non-GMP)
- Testing process robustness
Free up your time with UNICORN™ control software
Control your ÄKTA™ avant system in real time with UNICORN™ software. The software is easy to use, supports productivity and data security, and enables automation. You can create methods quickly, run unattended experiments, and evaluate results efficiently.
When scaling to larger ÄKTA™ systems, you’ll use the same UNICORN™ software.
Streamlined design of experiments (DoE) and mechanistic modeling workflows
DoE
The ÄKTA™ avant system is designed for execution of DoE experimental plans. Run unattended experiments (via inlet valves, column valves, fraction collector) and execute DoE experiments at different scales.
UNICORN™ DoE integrate extension enables you to automatically integrate your DoE experimental plans to UNICORN™ scouting runs. You’ll reduce the risk of errors and save time. You can do it from any commonly used DoE software available on the market.
Mechanistic modeling
The ÄKTA™ avant system is pre-characterized for mechanistic modeling: relevant system parameters are already included in GoSilico™ software. Furthermore, for calibration runs, data can be directly transferred from UNICORN™ software into GoSilico™ software, streamlining the modeling workflow.
Chromatography resins, adsorbers, columns, and capsules
We offer an extensive range of chromatography formats that can be used with the ÄKTA™ avant system. This includes:
- Prepacked columns, such as HiTrap™, HiScreen™, or Validation columns.
- Prepacked and precharacterized f(x) columns for mechanistic modeling.
- Empty columns, such as HiScale™ or AxiChrom™ columns.
- Fiber units: HiTrap Fibro™ and HiScreen Fibro™ units.
- Adsorber units, such as XT Acrodisc™ and Mustang™ XT capsules.
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