IMP-1700, Bacterial DNA repair inhibitor

Product Details

Formal Name: 1-Cyclopropyl-6-fluoro-4-oxo-7-(4-(4-(trifluoromethyl)phenyl)carbamothioyl)piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid

Molecular Formula: C₂₅H₂₂F₄N₄O₅S

Formula Weight: 534.5

CAS Number: 1458674-25-3

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to at least 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Bacterial DNA repair inhibitor

Functions

Potent inhibitor of the bacterial DNA double-strand break repair complex AddAB. It is capable of synergistic sensitization of methicillin-resistant staphylococcus aureus (MRSA) to ciprofloxacin (EC₅₀ = 0.6nM).  IMP-1700 is an important new tool for exploring new treatment options for drug resistant bacteria.

Application Procedures

First dissolved in DMSO (25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)