Fumarate hydratase-IN-1, Fumarate hydratase inhibitor

Product Details

Formal Name: Ethyl rel-(3S,3aR)-3-[2-(Methylamino)-2-oxoethyl]-2-oxo-1-[(4-phenylphenyl)methyl]-3,4,5,6-tetrahydroindole-3a-carboxylate

Molecular Formula: C₂₇H₃₀N₂O₄

Formula Weight: 446.6

CAS Number: 1644060-37-6

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (greater than 25 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Fumarate hydratase inhibitor

Functions

A pro-drug inhibitor of fumarate hydratase, an important enzyme in the tricarboxylic acid (TCA) cycle.  This cell permeable compound is converted to the active carboxylic acid by intracellular esterases (Ki = 4.5 µM for free acid).  The ethyl ester displayed cell-growth inhibitory activity against several cancer lines under nutrient (glucose) deprived conditions with an average IC₅₀ = 2.2 µM.

Application Procedures

First dissolved in DMSO (25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)