Synthesize oligonucleotides at scales of 10–150 mmol for early to mid-phase clinical trials or for diagnostic kits. This robust system has a footprint small enough to fit in a walk-in fume hood. Scale up easily with common UNICORN™ control software.
• Based on more than 30 years of collaboration with leading oligonucleotide pharma.
• Uses UNICORN™ control software for seamless scale-up from ÄKTA™ oligopilot™ plus oligo synthesizer to full-scale manufacturing with the OligoProcess™ system.
• Inline monitoring enables high degree of process control.
• Based on the same robust components as the OligoProcess™ synthesizer.
• Installation and Operation Qualification (IQ/OQ) documentation and performance support are available.
• Change control notification support available.
Produce one batch per day with fast-coupling capability. With well-trained staff, efficient standard operating procedures (SOPs), and secure supply, the OligoPilot™ oligonucleotide synthesizer can be part of a manufacturing train producing > 100 kg of oligonucleotides in a year.
The instrument fits easily into a walk-in fume hood. It is designed to be explosion proof according to ATEX Zone 2. Please refer to local legislation for guidance of local requirements.
UNICORN™ control software offered with this and other Cytiva products makes it easy to align your oligonucleotide synthesis with downstream processing, chromatography, and filtration, supporting an oligonucleotide development and manufacturing workflow.
Key Features
Based on more than 30 years of collaboration with leading oligonucleotide pharma.
Uses UNICORN™ control software for seamless scale-up from ÄKTA™ oligopilot™ plus oligo synthesizer to full-scale manufacturing with the OligoProcess™ system.
Inline monitoring enables high degree of process control.
Based on the same robust components as the OligoProcess™ synthesizer.
Installation and Operation Qualification (IQ/OQ) documentation and performance support are available.
Change control notification support available.
Specifications
Certificates
NFPA 70 Class 1 Division 2 is the correct standard for US market
Degree of protection
IP 55
Dimensions
~ 1000 × 1800 × 650 mm (exact dimensions pending final design)
Heat exchanger
Yes, pipe in tube
Monomer Inlets
17
No. of Waste Outlets
4
Operating pressure max.
10 bar g
Piping material
Stainless steel (316L)
Power
110 – 230 VAC, 50-60 Hz
Reagent and solvent inlets
10
Scale
10–150 mmol
Sensors
UV (254-700nm), Conductivity, Pressure, Flowmeter, Temperature
