Cluster of Differentiation 38 (CD38) is a multifunctional ectoenzyme expressed in many immune cells including CD4+, CD8+, B lymphocytes, and natural killer cells. CD38 serves as a hydrolase and a nicotinamide adenine dinucleotide (NAD+) cyclase, involved in the metabolism of nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP). The results are the production of Ca2+-mobilizing compounds, such as cyclic ADP ribose (cADPR) and ADP ribose (ADPR). CD38 is used as a marker for poor prognosis in chronic lymphocytic leukemia and multiple myeloma and is an attractive cancer immunotherapy drug target.
Tribioscience’s CD38 hydrolase Assay Kit is a simple and fast fluorometric assay that measures the hydrolase activity of CD38 in biological samples. CD38 catalyzes the conversion of substrate to a florescent product which can be measured by fluorometric method at Ex/Em=300 nm/410 nm.
Applications
Measure CD38 hydrolase activity in a variety of samples.
Screen CD38 hydrolase inhibitors.
Storage Conditions
Store the Reagent at -20°C, protect it from light. Shelf life: 12 months.
