Cytiva's Biacore™ 8 series SPR systems are engineered for demanding small‑molecule and biotherapeutic discovery. Deliver high‑quality affinity, kinetics, concentration, and yes/no binding data with enhanced capacity and sensitivity. Integrated plate handling for up to 12 plates eliminates the need for external automation, and provides seamless, precise results for confident decisions. Biacore™ 8 series systems are built for your needs in discovery today and the innovations of tomorrow.
- Flex between high-throughput screening and high-quality molecular characterization, in one robust SPR platform, minimizing capital spend while maximizing efficiency.
- Run hands-off with built-in automation, method queuing, and integrated plate handling of up to twelve 96- or 384-well microplates for 72 h.
- Screen faster with streamlined workflows—run 384 proteins in 15 min.
- Generate accurate kinetics across the full interaction spectrum, from the fastest to the slowest on- and off-rates.
- Analyze fragments, low-abundance analytes, and sensitive targets.
- Gain deeper insights from lower sample amounts with triple-parameter screening—concentration, kinetics, and epitope binning—in 66% less analysis time.
- Save up to 80 % data analysis time with supervised machine learning software and integrate data seamlessly into your organization's data management system.
Biacore™ 8 series SPR systems comparison
| |
Biacore™ 8S system |
Biacore™ 8S+ system |
Specification description and impact |
| Dissociation rate (kd) |
10-6 to 0.5 s-1
|
10-6 to 0.5 s-1
|
10-6 to 1 s-1 allows you to reliably determine molecules with very fast and slow off-rates. |
| Short term noise (RU(RMS)) |
Typically < 0.01 |
Typically < 0.01 |
Value < 0.01 allows you to separate sensorgrams and measure interactions down to milli-resonance unit (mRU), well suited for interactions with really slow off rates. Lower value compared to Biacore™ 8K and Biacore™ 8K+. |
| Analysis temperature (°C) |
4 to 40 |
4 to 40 |
In addition, temperature-controlled compartments for samples and analysis, ensure molecule stability and allows you to measure interactions with molecules in native and active stage. |
| Data collection rate (Hz) |
1 or 10 |
1 or 10 |
A data collection rate of 10 Hz gives the resolution of interactions and improves the accuracy of rapid on- and off-rate determinations. |
| Sample capacity |
up to 4 × 96- or 384-well microplates |
up to 12 × 96- or 384-well microplates |
Increase flexibility in sample capacity and volume, with opportunity to run > 4000 interactions in one go. |
| Flow cell addressing |
16 single or 8 pairwise |
16 single or 8 pairwise |
The number of flow cells indicate the analytical capacity – saving assay time, sample quantity, and sensor chips. |
| Unattended run time (h) |
60 |
72 |
A true walk-away solution for discovery with a minimum of manual intervention, increases the throughput and analytical efficiency especially combined with the activity queuing capability. |
| Speed to results |
Rapid screen 384 protein samples in 15 min
Rapid concentration of 384 protein samples in 24 min
Binding level screen of 384 small molecules in 4 h |
Rapid screen 384 protein samples in 15 min
Rapid concentration of 384 protein samples in 24 min
Binding level screen of 384 small molecules in 4 h |
Novel application tools not supported in Biacore™ 8K or
Biacore™ 8K+.
|
Biacore™ Insight Software
Biacore™ Insight Software streamlines the entire SPR workflow. From run to insight, the software enables fast, intuitive run setup, data analysis, and data integration to reduce time to results regardless of user experience or instrument model.
The modular, flexible design easily switches between application specific software tools and extensions for binding, affinity, kinetics, concentration, potency, sensorgram comparison, and epitope binning to support evolving research needs.
Optional 21 CFR Part 11 compliance, support provides seamless integration into regulated workflows when required.
Predefined methods
Biacore™ Insight control software includes predefined methods with application-relevant settings for major assays. Start experiments in minutes using these methods and Biacore™ SPR consumables.
View the Biacore™ Insight software product page.
Biacore™ consumables
Cytiva provides a range of tools for reliable and reproducible data with minimal effort:
- Series S sensor chips— All sensor chips are produced in a quality-controlled environment. Compatible with Biacore™ SPR system, these sensor chips support analysis of interactions from small organic molecules to viruses.
- Kits, buffers, and reagents— Reduce assay development time with consistent capture of antibodies and molecules via common tags. Ready-made buffers and solutions ensure reliable results and ease of use.
What's included
Included in Biacore™ 8S and Biacore™ 8S+ SPR systems are:
- Instrument, table with wheels, waste container,
- 2 licenses for Biacore™ Insight Software (product code 29310602),
- 2 licenses for Biacore™ Insight extended screening extension (product code 29310610),
- 2 licenses for Biacore™ Insight concentration and potency extension (29332204), and
- 2 licenses for Biacore™ Insight epitope binning extension (29478580)
Documents
