The B/B Homodimerizer is a membrane-permeant ligand that causes homodimerization of proteins fused to dimerization domain B (DmrB)—provided in the iDimerize Inducible Homodimer System (Cat. No. 635068). NOTE: The B/B Homodimerizer is identical to the AP20187 ligand previously supplied in the ARGENT Regulated Homodimerization Kit from ARIAD Pharmaceuticals, Inc.
Features
Previously available from ARIAD as the ARGENT Regulated Homodimerization Kit
Rapid chemical induction of cell signaling pathways
Activate any pathway or cellular event controlled by homo-oligomers (e.g., dimers, trimers, or tetramers)
Established tool used by over 2,000 research groups, with over 400 scientific publications to date
B/B Homodimerizer is identical to the AP20187 ligand
Applications
Product citations Burnett, S. H. et al. Conditional macrophage ablation in transgenic mice expressing a Fas-based suicide gene. J. Leukoc. Biol. 75, 612–623 (2004). Freeman, K. W. et al. Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional FGFR1-expressing mice. Ca
