Seraseq® Inherited Cardiovascular DNA Mix

Name: Seraseq® Inherited Cardiovascular DNA Mix
Brand: SeraCare
SKU: 0740-0132
Availability: InStock

Vendor: SeraCare

SKU: 0740-0132

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The Seraseq® Inherited Cardiovascular DNA Mix is a meticulously designed synthetic DNA reference material, engineered to empower laboratories in the development, validation, and routine monitoring of next-generation sequencing (NGS) and other molecular assays targeting inherited cardiovascular diseases.

This comprehensive mix encompasses 61 clinically-relevant mutations across 56 genes, representing all major cardiomyopathy types, including hypertrophic, dilated, restrictive, and arrhythmogenic cardiomyopathies, as well as arrhythmias and other related syndromes.

FEATURES AND BENEFITS

Comprehensive Variant Coverage for Inherited Cardiovascular Diseases: contains 61 carefully selected mutations in 56 genes, ensuring broad representation of clinically significant variants linked to all major inherited cardiovascular diseases.

Expertly Designed: crafted to mimic challenging genomic regions such as microsatellite instability, large deletions in repetitive regions, and large duplications; providing a robust tool for clinical laboratories working on inherited cardiovascular conditions.

Clinically Relevant Mutations: all 61 variants are classified as pathogenic or likely pathogenic, adhering to ACMG recommendations, the FDA-recognized database, and/or an expert-reviewed panel.

Single-Vial Convenience: Simplify workflows with a highly multiplexed reference material packaged in a single vial, reducing costs and saving time while boosting QC consistency.

High-Quality Synthetic DNA: manufactured in cGMP compliant and ISO 13485-certified facilities with precision to ensure accurate and reproducible results, providing confidence in your assay performance. Variants quantified using sensitive dPCR assays and blended with the well-characterized GM24385 genomic background. Orthogonally validated by a targeted NGS panel.

Specifications

Genes	56 genes: ABCC9, ACTC1, ACTN2, ALPK3, BAG3, CACNA1C, CALM1, CALM2, CASQ2, CDH2, CTNNA3, CRYAB, DES, DMD, DSC2, DSG2, DSP, EMD, FKTN, FLNC, GAA, GATA6, GLA, HCN4, JPH2, JUP, LAMP2, LDB3, LMNA, MYBPC3, MYH6, MYH7, MYL2, MYL3, MYPN, NEXN, NKX2-5, PKP2, PLN, PPA2, PRDM16, PRKAG2, PTPN11, RAF1, RBM20, RYR2, SCN5A, TMEM43, TNNC1, TNNI3, TNNI3K, TNNT2, TPM1, TTR, TTN, SHOC2
Variants	61 mutations (see the Product Sheet (MKT-01147), the Technical Product Report or the Technical Spreadsheet (MKT-01045) available in the Resources tab for exact details.
Disease Coverage	Hypertrophic, dilated, restrictive, and arrhythmogenic cardiomyopathies, arrhythmias, and other related syndromes. See the technical Spreadsheet (MKT-01045) available in the Resources tab for more information.
Nominal Concentration	10 ng/µL (see the Technical Product Report for the exact concentration)
Format	Purified DNA
Fill Volume	1 vial x 25 µL
Total Mass	>250 ng
Expected Variant Allele Frequencies (VAFs)	~50%
Buffer	1 mM Tris, 0.1 mM EDTA; pH 8.0 aqueous

Documents

Ordering Information

Cat. no.	Product	Size
0740-0132	Seraseq® Inherited Cardiovascular DNA Mix	1 x 25 µL

Specifications

Format Purified DNA
Pack size 1 x 25 µL

links and documants

Datasheet url Click here
Ifu url Click here
Msds url Click here
Source url Click here