Seraseq® ctDNA Complete™ Mutation Mix

To further accelerate the validation and clinical application of liquid biopsy-based ccfDNA-targeted NGS assays, SeraCare has developed the Seraseq ctDNA Complete that expands coverage of all relevant variant types including SNVs, INDELs, CNVs, and gene fusions in a single highly-multiplexed reference sample. These new products are offered in either a purified ctDNA format or a plasma-like matrix format, all precisely quantitated by digital PCR against a single well-characterized genomic background (GM24385), and orthogonally validated with NGS technology.

• 25 unique multiplexed variants in 16 genes, covering 12 SNVs, 7 INDELs, 3 CNVs, and 3 SVs, in purified and plasma-like matrix formats.
• 6 different allele frequencies available: wild-type, 0.1%, 0.5%, 1%, 2.5%, and 5%
• Allows end-to-end evaluation of assay performance across the entire workflow, including pre-analytic extraction steps
• Variants quantitated with digital PCR and orthogonally validated by NGS
• Blends with well-characterized GM24385 human genomic DNA as background wild-type material
• Manufactured within cGMP-compliant and ISO 13485-certified facilities.

Specifications

Documents

• Seraseq® ctDNA Complete™ Reference Materials Product Sheet (Product Sheet)
• Seraseq ctDNA Complete Mutation Mix AF5%, AF2.5%, AF1%, AF0.5%, AF0.1%, WT (Wild-Type) (Package Insert)
• Technical Spreadhseet for Seraseq ctDNA Complete Mutation Mix and Reference Material (Technical Spreadsheet)
• Seraseq ctDNA Complete Mutation Mix Non-Requirement Letter (SDS Non-Requirement Letter)

Ordering Information