Hedera Profiling 1 DNA Tissue Test Panel (HP1 FFPE), 115-Gene NGS Tumor Profiling Kit, 48 Tests

Hedera Profiling 1 (HP1 FFPE) is a 115-gene, hybrid-capture NGS panel for profiling the most common solid tumors from FFPE tissue DNA. A single DNA-only assay detects SNVs, Indels, CNVs, Fusions and MSI and covers all NCCN-guideline and ESCAT Level I genomic targets. 48 tests per kit, in a manual or an automation-ready format.

Kits are commercialized together with the Hedera Prime software and can be purchased separately.

Key Features

• Compact but comprehensive: 115-gene panel for the detection of SNVs, Indels, CNVs, Fusions and MSI across all tumor types in a single, DNA-only assay
• Highly actionable: Covers all NCCN-guideline and ESCAT Level I genomic targets in solid tumors
• Fast and accurate: Swiftly integrates into your routine NGS workflow to get accurate results with low input material within 5 calendar days
• Robust software analysis: Backed by Hedera Prime software, it saves time on each report while ensuring accurate and reliable results
• Unique fusions detection method on DNA: Cutting-edge proprietary technology to detect fusions with unmatched precision, enhancing the accuracy of complex variants detection

Workflow

The kit integrates into your existing NGS workflow and sequencing instrument; tertiary analysis and reporting run in the Hedera Prime software.

• 3 hours - hands on time
• 5 calendar days - from sample to report
• < 5 minutes - tertiary analysis & reporting

Specifications

Gene List

Tumor types: Lung Cancer, Colorectal Cancer, Melanoma, Thyroid Cancer, Gastrointestinal Stromal Tumors (GIST), Cholangiocarcinoma and other solid tumors.

AKT1, ALK, APC, AR, ARAF, AR Enhancer, ARID1A, ARID1B, ATM, ATR, ATRX, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CCND1, CCNE1, CD274, CDK12, CDK4, CDKN2A, CDKN2B, CHEK1, CHEK2, CIC, CLDN18, CTNNB1, CUL3, DDR2, DICER1, EGFR, EPCAM, ERBB2, ERBB3, ERBB4, ERCC2, ESR1, FANCA, FANCL, FAT1, FBXW7, FGFR1, FGFR2, FGFR2b, FGFR3, FGFR4, FOXL2, GNA11, GNAQ, GNAS, H3-3A, H3-3B, HIST1H3B, HIST1H3C, HIST1H3H, HRAS, IDH1, IDH2, KEAP1, KIT, KLF4, KRAS, MAP2K1, MAP2K2, MDM2, MEN1, MET, MLH1, MRE11, MSH2, MSH6, MTAP, MTOR, MYC, NBN, NF1, NFE2L2, NOTCH1, NRAS, NTRK1, NTRK2, NTRK3, PALB2, PDCD1, PDGFRA, PIK3CA, PIK3R1, PMS2, POLD1, POLE, PPARG, PPP2R1A, PPP2R2A, PTCH1, PTEN, PTPN11, RAD51B, RAD51C, RAD51D, RAD54L, RAF1, RB1, RET, ROS1, SMAD4, SMARCA4, SMARCB1, SMO, STK11, TACSTD2, TERT Promoter, TP53, TRAF7, TSC1, TSC2, VHL

Ordering Information

For Research Use Only. Not for use in diagnostic procedures. This product is intended for laboratory research purposes only and is not intended for use in the diagnosis, prevention, monitoring, treatment, or alleviation of disease. This product has not been cleared or approved by any regulatory authority for clinical or diagnostic use.