Hedera Profiling 1 ctDNA Test Panel (HP1 ctDNA), 115-Gene NGS Liquid Biopsy Kit, 24 Tests

Hedera Profiling 1 ctDNA (HP1 ctDNA) brings the 115-gene HP1 design to liquid biopsy: a hybrid-capture NGS panel that detects SNVs, Indels, CNVs, Fusions, MSI and tumor fraction from plasma cfDNA in one DNA-only assay, covering all NCCN-guideline and ESCAT Level I targets. 24 tests per kit.

Kits are commercialized together with the Hedera Prime software and can be purchased separately.

Key Features

• Compact but comprehensive: 115-gene panel for the detection of SNVs, Indels, CNVs, Fusions and MSI across all tumor types in a single, DNA-only assay
• Highly actionable: Covers all NCCN-guideline and ESCAT Level I genomic targets in solid tumors
• Fast and accurate: Swiftly integrates into your routine NGS workflow to get accurate results with low input material within 5 calendar days
• Robust software analysis: Backed by Hedera Prime software, it saves time on each report while ensuring accurate and reliable results
• Unique fusions detection method on DNA: Cutting-edge proprietary technology to detect fusions with unmatched precision, enhancing the accuracy of complex variants detection

Workflow

The kit integrates into your existing NGS workflow and sequencing instrument; tertiary analysis and reporting run in the Hedera Prime software.

• 3 hours - hands on time
• 5 calendar days - from sample to report
• < 5 minutes - tertiary analysis & reporting

Specifications

Gene List

Tumor types: Lung Cancer, Colorectal Cancer, Melanoma, Thyroid Cancer, Gastrointestinal Stromal Tumors (GIST), Cholangiocarcinoma and other solid tumors.

AKT1, ALK, APC, AR, ARAF, AR Enhancer, ARID1A, ARID1B, ATM, ATR, ATRX, BARD1, BRAF, BRCA1, BRCA2, BRIP1, CCND1, CCNE1, CD274, CDK12, CDK4, CDKN2A, CDKN2B, CHEK1, CHEK2, CIC, CLDN18, CTNNB1, CUL3, DDR2, DICER1, EGFR, EPCAM, ERBB2, ERBB3, ERBB4, ERCC2, ESR1, FANCA, FANCL, FAT1, FBXW7, FGFR1, FGFR2, FGFR2b, FGFR3, FGFR4, FOXL2, GNA11, GNAQ, GNAS, H3-3A, H3-3B, HIST1H3B, HIST1H3C, HIST1H3H, HRAS, IDH1, IDH2, KEAP1, KIT, KLF4, KRAS, MAP2K1, MAP2K2, MDM2, MEN1, MET, MLH1, MRE11, MSH2, MSH6, MTAP, MTOR, MYC, NBN, NF1, NFE2L2, NOTCH1, NRAS, NTRK1, NTRK2, NTRK3, PALB2, PDCD1, PDGFRA, PIK3CA, PIK3R1, PMS2, POLD1, POLE, PPARG, PPP2R1A, PPP2R2A, PTCH1, PTEN, PTPN11, RAD51B, RAD51C, RAD51D, RAD54L, RAF1, RB1, RET, ROS1, SMAD4, SMARCA4, SMARCB1, SMO, STK11, TACSTD2, TERT Promoter, TP53, TRAF7, TSC1, TSC2, VHL

Ordering Information

For Research Use Only. Not for use in diagnostic procedures. This product is intended for laboratory research purposes only and is not intended for use in the diagnosis, prevention, monitoring, treatment, or alleviation of disease. This product has not been cleared or approved by any regulatory authority for clinical or diagnostic use.