Archer VARIANTPlex Expanded Solid Tumor Panel

Discover key DNA signatures of multiple cancers with one panel

Efficiently detect single nucleotide variants, insertions, deletions, copy number variations, and microsatellite instability with targeted NGS of 76 relevant genes for colorectal, breast, melanoma, pancreatic, NSCLC and other pan-cancer research.

Key Benefits

• Detect confidently — Archer’s unique outlier detection algorithm leverages position-specific data to enable variant detection even at low allele frequencies, while Archer Analysis makes providing answers easy.
• Less QNS — Anchored Multiplex PCR (AMP™) chemistry is designed for compatibility with a wide variety of sample types, including low-input and potentially degraded samples such as FFPE tissue.
• Achieve efficiency — Streamlined workflows for your lab are enabled by choice of reaction-sized lyophilized reagents or high-throughput liquid reagents, while parallel workflows across all Archer panels provide efficient genomic characterization.
• Customize content — Use Assay Marketplace to modify any panel to fit your lab's needs or start from scratch to keep up with the pace of discovery.

Panel Specifications

*Input mass requirements vary depending on type and quality. Unless the tumor cellularity and sample quality are high, 50 ng of FFPE-derived nucleic acid should be considered the minimum recommendation. If input is not limiting, 200 ng is recommended.

Gene Targets

AKT1, BRAF, EGFR, ERBB2, FOXL2, GNA11, GNAQ, GNAS, HRAS, IDH1, IDH2, KIT, KRAS, MET, NRAS, PDGFRA, PIK3CA, RET, TERT, TP53, ALK, APC, AR, ATRX, CDK4, CDK6, CDKN2A, CTNNB1, DDR2, ERBB3, ERBB4, ESR1, FBXW7, FGFR1, FGFR2, FGFR3, H3F3A, HIST1H3B, JAK2, MAP2K1, MAP2K2, MTOR, MYC, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NTRK1, NTRK2, NTRK3, POLD1, POLE, PTEN, RAF1, RB1, RICTOR, ROS1, SMAD4, SMO, VHL, ATM, BARD1, BRCA1, BRCA2, BRIP1, CDK12, CHEK1, CHEK2, FANCA, FANCL, PALB2, RAD51B, RAD51C, RAD51D, RAD54L, STK11

Documents

User guides and protocols

• VARIANTPlex-HT Protocol for Illumina (PDF)
• VARIANTPlex HS-HGC Protocol for Illumina (PDF)

Product inserts

• VARIANTPlex-HT Expanded Solid Tumor Panel Product Insert (PDF)
• VARIANTPlex Expanded Solid Tumor Product Insert (PDF)

Ordering Information

HT kits are liquid reagents for high-throughput / automated workflows (Illumina only). For research use only. Not for use in diagnostic procedures.