Archer VARIANTPlex Core Solid Tumor Panel

Identify DNA profiles of multiple cancers with one core panel

Efficiently detect single nucleotide variants, insertions and deletions, copy number variations, and microsatellite instability with targeted NGS of 60 genes relevant for colorectal, breast, melanoma, pancreatic, NSCLC, and other cancer research.

Key Benefits

• Detect confidently — A unique outlier detection algorithm leverages position-specific data to enable variant detection even at low allele frequencies, one of the many ways that Archer Analysis empowers you to detect confidently.
• Less QNS — Anchored Multiplex PCR (AMP™) chemistry is designed for compatibility with a wide range of sample types, including low-input and potentially degraded samples such as FFPE tissue.
• Achieve efficiency — Streamlined workflows for your lab are enabled by choice of reaction-sized lyophilized reagents or high-throughput liquid reagents, while parallel workflows across all Archer panels provide efficient genomic characterization.
• Customize content — Use Assay Marketplace to modify any panel to fit your lab's needs or start from scratch to keep up with the pace of discovery.

Panel Specifications

*Input mass requirements vary depending on type and quality. Unless the tumor cellularity and sample quality are high, 50 ng of FFPE-derived nucleic acid should be considered the minimum recommendation. If input is not limiting, 200 ng is recommended.

Gene Targets

AKT1, BRAF, EGFR, ERBB2, FOXL2, GNA11, GNAQ, GNAS, HRAS, IDH1, IDH2, KIT, KRAS, MET, NRAS, PDGFRA, PIK3CA, RET, TERT, TP53, ALK, APC, AR, ATRX, CDK4, CDK6, CDKN2A, CTNNB1, DDR2, ERBB3, ERBB4, ESR1, FBXW7, FGFR1, FGFR2, FGFR3, H3F3A, HIST1H3B, JAK2, MAP2K1, MAP2K2, MTOR, MYC, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NTRK1, NTRK2, NTRK3, POLD1, POLE, PTEN, RAF1, RB1, RICTOR, ROS1, SMAD4, SMO, VHL

Documents

User guides and protocols

• VARIANTPlex-HT Protocol for Illumina (PDF)
• VARIANTPlex HS-HGC Protocol for Illumina (PDF)

Product inserts

• VARIANTPlex-HT Core Solid Tumor Panel Product Insert (PDF)
• VARIANTPlex Core Solid Tumor Product Insert (PDF)

Ordering Information

HT kits are liquid reagents for high-throughput / automated workflows (Illumina only). For research use only. Not for use in diagnostic procedures.