Archer FUSIONPlex Myeloid Panel

Discover myeloid insights with a targeted RNA panel

Identify known and novel fusions, splice variants, expression levels, single nucleotide variants, insertions, and deletions with targeted NGS of 84 genes relevant for acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), and myelodysplastic syndromes (MDS) research.

Key Benefits

• Detect more — Comprehensive fusion detection is enabled by open-ended targeted amplification, delivering detection of both novel and known fusions, while Archer Analysis’s multifeatured pipeline provides data confidence and clear visualization of breakpoints.
• Less QNS — Anchored Multiplex PCR (AMP™) chemistry is designed for compatibility with a wide range of sample types, including low-input and degraded samples such as FFPE tissue.
• Achieve efficiency — Streamlined workflows for your lab are enabled by choice of reaction-sized lyophilized reagents or high-throughput liquid reagents, while parallel workflows across all Archer panels provide efficient genomic characterization.
• Customize content — Use Assay Marketplace to modify any panel to fit your lab’s needs or start from scratch to keep up with the pace of discovery.

Panel Specifications

*Input mass requirements vary depending on type and quality. Unless the tumor cellularity and sample quality are high, 50 ng of FFPE-derived nucleic acid should be considered the minimum recommendation. If input is not limiting, 200 ng is recommended.

†Liquid reagents available for Illumina platform only.

Gene Targets

ABL1, AKT3, ASXL1, BCR, BRAF, CALR, CBFB, CBL, CD274, CEBPA, CHD1, CHIC2, CREBBP, CSF1R, CSF3R, CTLA4, DCK, DNM2, DNMT3A, ERG, ETV6, EZH2, FBXW7, FGFR1, FGFR2, FGFR3, FLT3, GATA1, GATA2, GLIS2, GNAS, ID4, IDH1, IDH2, IKZF1, IKZF3, IRF4, IRF8, JAK1, JAK2, JAK3, KAT6A, KDM6A, KIT, KMT2A, KRAS, MECOM, MKL1, MLLT10, MLLT4, MPL, MUC1, MYC, MYD88, MYH11, NF1, NOTCH1, NPM1, NRAS, NUP214, NUP98, PDCD1, PDCD1LG2, PDGFRA, PDGFRB, PHF6, PICALM, PML, PTPN11, RARA, RBM15, ROS1, RUNX1, RUNX1T1, SETBP1, SETD2, SF3B1, SLC29A1, SRSF2, TCF3, TFG, U2AF1, WT1, XPO1

Documents

User guides and protocols

• FUSIONPlex Protocol for Ion Torrent (PDF)
• FUSIONPlex Protocol for Illumina (PDF)
• FUSIONPlex-HT Protocol for Illumina (PDF)

Product inserts

• FUSIONPlex-HT Myeloid Panel Product Insert (PDF)
• FUSIONPlex Myeloid Product Insert (PDF)

Ordering Information

HT kits are liquid reagents for high-throughput / automated workflows (Illumina only). For research use only. Not for use in diagnostic procedures.