Archer FUSIONPlex Core Solid Tumor Panel

Discover key solid tumor insights with a targeted RNA panel first

Identify known and novel fusions, splice variants, single nucleotide variants, insertions, deletions, and relative RNA expression with targeted NGS of 57 core genes relevant for colorectal, breast, melanoma, thyroid, gastric, pancreatic, CNS, NSCLC, and other cancer research.

Detect more with Archer FUSIONPlex NGS panels for RNA.

Key Benefits

• Detect more — Comprehensive fusion detection is enabled by open-ended targeted amplification, delivering identification of both novel and known fusions, while Archer Analysis's multifeatured pipeline provides data confidence and clear visualization of breakpoints.
• Less QNS — Anchored Multiplex PCR (AMP™) chemistry is designed for compatibility with a wide variety of sample types, including low-input and potentially degraded samples such as FFPE tissue.
• Achieve efficiency — Streamlined workflows for your lab are enabled by choice of reaction-sized lyophilized reagents or high-throughput liquid reagents, while parallel workflows across all Archer panels provide efficient genomic characterization.
• Customize content — Use Assay Marketplace to modify any panel to fit your lab's needs or start from scratch to keep up with the pace of discovery.

Panel Specifications

*Input mass requirements vary depending on type and quality. Unless the tumor cellularity and sample quality are high, 50 ng of FFPE-derived nucleic acid should be considered the minimum recommendation. If input is not limiting, 200 ng is recommended.

†Liquid reagents available for Illumina platform only.

Gene Targets

AKT1, ALK, AXL, BRAF, BRD3, BRD4, CTNNB1, CYSLTR2, DDR2, DNAJB1, EGFR, ERBB2, ERBB4, ERG, ESR1, FGFR1, FGFR2, FGFR3, GNA11, GNAQ, GNAS, H3F3A, HIST1H3B, HRAS, IDH1, IDH2, KEAP1, KIT, KRAS, LTK, MAP2K1, MAP3K3, MAP3K8, MET, MYB, MYBL1, NRAS, NRG1, NTRK1, NTRK2, NTRK3, NUTM1, PAX8, PDGFRA, PIK3CA, POLD1, POLE, PPARG, PRKCA, PRKCB, RAF1, RET, ROS1, STK11, TMPRSS2, TP53, TRIM11

Documents

User guides and protocols

• FUSIONPlex Protocol for Ion Torrent (PDF)
• FUSIONPlex Protocol for Illumina (PDF)
• FUSIONPlex-HT Protocol for Illumina (PDF)

Product inserts

• FUSIONPlex-HT Core Solid Tumor Panel Product Insert (PDF)
• FUSIONPlex Core Solid Tumor Product Insert (PDF)

Posters

• Comprehensive genomic profiling using VARIANTPlex and FUSIONPlex panels along with Archer’s new tumor-only homologous recombination deficiency algorithm poster (PDF)

Ordering Information

HT kits are liquid reagents for high-throughput / automated workflows (Illumina only). For research use only. Not for use in diagnostic procedures.