Archer FUSIONPlex Acute Lymphoblastic Leukemia Panel

SKU: AB0013

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Discover ALL insights with a targeted RNA panel

Identify known and novel fusions, splice variants, single nucleotide variants, insertions, deletions, and expression levels with targeted NGS of 81 genes relevant for acute lymphoblastic leukemia research.

Key Benefits

Detect more — Comprehensive fusion identification is enabled by open-ended targeted amplification, delivering detection of both novel and known fusions, while Archer Analysis’s multifeatured pipeline provides data confidence and clear visualization of breakpoints.
Less QNS — Anchored Multiplex PCR (AMP™) chemistry is designed for compatibility with a wide range of sample types, including low-input and degraded samples such as FFPE tissue.
Achieve efficiency — Streamlined workflows for your lab are enabled by choice of reaction-sized lyophilized reagents or high-throughput liquid reagents, while parallel workflows across all Archer panels provide efficient genomic characterization.
Customize content — Use Assay Marketplace to modify any panel to fit your lab’s needs or start from scratch to keep up with the pace of discovery.

Panel Specifications

Targeted genes	81
Genomic alterations	Fusions, splicing, exon-skipping, SNVs, indels, expression levels
Input nucleic acid required*	≥10 ng
Recommended number of reads	1.5 M
Hands-on time	<3.5 hours
Total library prep time	1.5 days
Platform compatibility	Illumina® and Ion Torrent™
Reagent format	Lyophilized or liquid†
Supported sample types	Blood, bone marrow, fresh frozen, FFPE, BMMC, PBMC

*Input mass requirements vary depending on type and quality. Unless the tumor cellularity and sample quality are high, 50 ng of FFPE-derived nucleic acid should be considered the minimum recommendation. If input is not limiting, 200 ng is recommended.

†Liquid reagents available for Illumina platform only.

Gene Targets

ABL1, ABL2, AICDA, BCL11B, BCL2, BCL6, BCR, BLNK, BRAF, CD274, CHD1, CREBBP, CRLF2, CSF1R, CTLA4, DNM2, DNTT, EBF1, EPOR, ETV6, EZH2, FBXW7, FGFR1, FLT3, HOXA10, HOXA9, IDH1, IDH2, IKZF1, IKZF2, IKZF3, IL7R, IRF4, IRF8, JAK1, JAK2, JAK3, KDM6A, KLF2, KMT2A, KRAS, LMO1, LYL1, MLLT4, MPL, MYC, NF1, NOTCH1, NRAS, NT5C2, NTRK3, NUP214, NUP98, P2RY8, PAG1, PAX5, PBX1, PDCD1, PDCD1LG2, PDGFRA, PDGFRB, PICALM, PTK2B, PTPN11, RAG1, RAG2, RUNX1, SEMA6A, SETD2, SH2B3, SOX11, STAT3, STAT5B, STIL, TAL1, TCF3, TLX1, TLX3, TYK2, WT1, ZCCHC7

Documents

User guides and protocols

Product inserts

Ordering Information

Cat. #	Kit	Format
AB0013	FUSIONPlex ALL ILMN 8rxn	Illumina / 8 rxn
AB0014	FUSIONPlex ALL IONT 8rxn	Ion Torrent / 8 rxn
AB0177	FUSIONPlex-HT ALL ILMN 24rxn	HT / Illumina / 24 rxn
AB0178	FUSIONPlex-HT ALL ILMN 96rxn	HT / Illumina / 96 rxn

HT kits are liquid reagents for high-throughput / automated workflows (Illumina only). For research use only. Not for use in diagnostic procedures.

Specifications

Assay time 1.5 days
Content specifications 81 genes
Hands on time <3.5 hours
Input quantity ≥10 ng
Platform compatibility Illumina and Ion Torrent
Reagent type Lyophilized or liquid
Specialized sample types Blood, bone marrow, fresh frozen, FFPE, BMMC, PBMC
Sub category FUSIONPlex
Variant class Fusions, splicing, exon-skipping, SNVs, indels, expression levels

links and documants

Datasheet url Click here
Protocol url Click here
Source url Click here