YM-155, Survivin inhibitor

Product Details

Formal Name: 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide

Alternate Names: Sepantronium bromide

Molecular Formula: C₂₀H₁₉BrN₄O₃

Formula Weight: 443.30

CAS Number: 781661-94-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Survivin inhibitor

Functions

A novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members. Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer. Induces DNA damage. Induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.

Application Procedures

First dissolved in DMSO (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)