Solubility: Soluble in DMSO (up to at least 25 mg/ml)
Storage: -20°C
Stability: ≥ 1 year.
Applications
JAK/STAT3 inhibitor
Functions
WP1066 (857064-38-1) is an inhibitor of the JAK2/STAT3 pathway as well as STAT5 and AKT. It downregulated Bcl-XL, Mcl-1, and c-myc while activating Bax and inducing apoptosis. Active against human malignant glioma U87-mg(IC50 = 5.6µM) and U373-mg(IC50 = 3.7µM) cells. Enhances T-cell cytotoxicity via inhibition of regulatory T-cells. WP1066 abrogated PD-L1 expression in lymphoma cell lines.
Application Procedures
First dissolved in DMSO (up to at least 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
