WH-4-023, Src family inhibitor

Product Details

Formal Name: N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-carbamic acid, 2,6-dimethylphenyl ester

Molecular Formula: C₃₂H₃₆N₆O₄

Formula Weight: 568.70

CAS Number: 837422-57-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (60 mg/ml)

Storage: -20°C

Stability: ≥ 2 years.

Applications

Src family inhibitor

Functions

Potent and selective inhibitor of Src family kinases Lck and Src, IC50=2 and 6 nM respectively. Also inhibits SIK, IC50=10, 22 and 60 nM for SIK 1, 2 and 3 respectively. May be used along with PD-325901 and CHIR-99021 to support self-renewal of naïve human embryonic stem cells.

Application Procedures

First dissolved in DMSO (60 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)