VAS-2870, Nox inhibitor

Product Details

Formal Name: 3-Benyl-7-(2-benzoxazolyl)yhio-1,2,3-triazolo(4,5-d)pyrimidine

Molecular Formula: C₁₈H₁₂N₆OS

Formula Weight: 360.40

CAS Number: 722456-31-7

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 10 mg/ml) or in DMF (up to 25 mg/ml).

Storage: RT

Stability: ≥ 2 years.

Applications

Nox inhibitor

Functions

NAD(P)H oxidase (Nox) inhibitor.  Abolishes PDGF-mediated Nox activation and ROS production (100% at 10  μM). Inhibits PMA-induced oxidative burst in HL-60 cells (IC50=2 µM). Enhances TGF-ß-induced apoptosis in liver tumor cells.

Application Procedures

First dissolved in DMSO (up to 10 mg/ml) or in DMF (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)