Varenicline tartrate, α4ß2 partial agonist

Product Details

Formal Name: 7,8,9,10-Tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline tartrate:7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino(2,3-h)(3)benzazepine tartrate

Alternate Names: Chantix; CP-526,555-18

Molecular Formula: C₁₃H₁₃N₃·C₄H₆O₆

Formula Weight: 361.4

CAS Number: 375815-87-5

Purity: >98%

Formulation: Powder

Solubility: Soluble in DMSO (up to 18 mg/ml) or in Water (up to 35 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

α4ß2 partial agonist

Functions

Varenicline is a partial agonist of the α4β2 neuronal nicotinic acetylcholine receptor (EC₅₀ = 2.3 µM) and a full agonist at α7 neuronal nicotinic receptors. Clinically useful smoking cessation agent.

Application Procedures

First dissolved in DMSO (18 mg/ml) or water (35 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or water may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)