Urolithin A, Mitophagy inducer

Product Details

Formal Name: 3,8-Dihydroxy-6H-dibenzo[b,d]pyran-6-one; or 2′,7-Dihydroxy-3,4-benzocoumarin

Molecular Formula: C₁₃H₈O₄

Formula Weight: 228.20

CAS Number: 1143-70-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO up to 50 mg/ml

Storage: -20°C

Stability: ≥ 2 years.

Applications

Mitophagy inducer

Functions

Urolithin A (UA) is a microbial metabolite of dietary ellagitannins produced in the gut. It has been shown to induce mitophagy and prolong lifespan in C. elegans and increase muscle function in rodents. It promotes mitophagy and suppresses NLRP3 inflammasome activation in LPS-induced BV2 microglial cells and in an MPTP-induced Parkinson’s disease model. The pro-mitophagy activity of UA may be beneficial in Alzheimer’s disease. Ex vivo UA-treated T cells display improved anti-tumor function.

Application Procedures

First dissolved in DMSO up to 50 mg/ml, then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)