Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Storage: -20°C
Stability: ≥ 2 years.
Applications
ER stress inducer
Functions
Fermentation product from Streptomyces lysosuperificus. Provided as a mixture of tunicamycin A (C14), B (C15), C (C16) and D (C17) homologs varying in the number of carbon atoms in the fatty acid chain.
Potent inhibitor of GlcNAc phosphotransferase which thereby inhibits glycoprotein biosynthesis. Causes endoplasmic reticulum stress-induced autophagy and unfolded protein response. Arrests cell cycle in late G1.
Application Procedures
First dissolved in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
