TUDCA, ER stress inhibitor

Product Details

Formal Name: 3α,7β-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide

Alternate Names: Tauroursodeoxycholic acid; Tauroursodeoxycholate

Molecular Formula: C₂₆H₄₅NO₆S

Formula Weight: 499.7

CAS Number: 14605-22-2

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (30 mg/ml) or in Ethanol (20 mg/ml with warming)

Storage: -20°C

Stability: ≥ 2 years.

Applications

ER stress inhibitor

Functions

A classic inhibitor of endoplasmic reticulum (ER) stress. Reduces ER stress and adipose tissue inflammation in a mouse model of high fat diet-induced obesity. Blocks ER stress-induced NLRP3 inflammasome activation and hepatocyte death. Attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mouse model.

Application Procedures

First dissolved in DMSO (30 mg/ml) or in ethanol (20 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)