TTNPB, Retinoic RAR agonist

Product Details

Formal Name: 4-[(E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]benzoic acid

Alternate Names: Ro 13-7410; AGN-191183; Arotinoid acid

Molecular Formula: C₂₄H₂₈O₂

Formula Weight: 348.50

CAS Number: 71441-28-6

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 4 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Retinoic RAR agonist

Functions

A highly potent and selective retinoic acid analog acting as an RAR agonist (EC50 = 21, 4 and 2.4 nM for RARα, RARβ and RARγ respectively). TTNPB has been extensively used in stem cell differentiation protocols. It enhances reprogramming efficiency in chemically induced pluripotent stem cells. Chondrocytes are robustly induced from human pluripotent stem cells by treatment with CHIR99021 and TTNPB. TTNPB alone, efficiently converts primary adult mouse fibroblasts into dermal papilla cell-like cells. Can be used in combination with other small molecules for induction of mouse totipotent stem cells.

Application Procedures

First dissolved in DMSO (up to 4 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)