TTFA, Mitochondrial Complex II inhibitor

Product Details

Formal Name: 4,4,4-Trifluoro-1-(2-thienyl)-1,3-butanedione

Molecular Formula: C₈H₅F₃O₂S

Formula Weight: 222.18

CAS Number: 326-91-0

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)

Storage: -20°C

Stability: ≥ 1 year.

Applications

Mitochondrial Complex II inhibitor

Functions

TTFA blocks the respiratory chain complex II causing inhibition of mitochondrial respiration.  Respiratory chain complex II inhibition is caused via binding of TTFA to two ubiquinone binding sites, Qp and Qd. Inhibition of Complex II by TFA has been shown to cause a delay in overall cell cycle progression leading to oxidative stress. TTFA also was found to inhibit porcine liver carboxylesterase (IC50 = 0.54 µM).

Application Procedures

First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or Ethanol may be stored at -20°C for up to 1 month.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)