Tranylcypromine hemisulfate (±), Demethylase inhibitor

Product Details

Formal Name: Trans (±)-2-phenylcyclopropanamine, hemisulfate salt

Alternate Names: 2-PCPA; SKF-385

Molecular Formula: C₉H₁₁N ∙ 1/2(H₂SO₄)

Formula Weight: 182.23

CAS Number: 13492-01-8

Purity: >98%

Formulation: powder

Solubility: Soluble in Water (up to 25 mg/ml).

Storage: -20°C

Stability: ≥ 1 year.

Applications

Demethylase inhibitor

Functions

Irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) IC50  < 2 µM. Tranylcypromine treatment of P19 embryonal carcinoma cells resulted in global increase of H3K4 methylation along with transcriptional derepression of two BHC110 target genes, Egr1 and Oct4. When combined with CHIR99021, induces the generation of human-induced pluripotent stem cells in the absence of exogenous Sox2.  Reduces proliferation, cell cycle progression and invasiveness of endometriotic stromal cells. Upregulates CD86 expression in THP1 cells. Monoamine oxidase inhibitor. Cell permeable and active in vivo.

Application Procedures

First dissolved in Water (up to 25 mg/ml), then diluted to aqueous buffer. Solutions in distilled water may be stored at -20° for up to 3 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)