Torin 1, mTOR inhibitor

Product Details

Formal Name: 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one

Molecular Formula: C₃₅H₂₈F₃N₅O₂

Formula Weight: 607.60

CAS Number: 1222998-36-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 8 mg/ml with warming)

Storage: -20°C

Stability: ≥ 2 years.

Applications

mTOR inhibitor

Functions

Potent and selective ATP-competitive mTOR inhibitor, IC50=2 and 10 nM for mTORC1 and mTORC2 respectively. Active in vivo at inhibition of mTOR-mediated effects in mice (20 mg/kg). Induces autophagy. Torin 1-mediated enhancement of TFEB-mediated autophagy alleviates neuronal death in oxidative stress-induced disease models. Downregulates NGF expression in RSC96 cells.

Application Procedures

First dissolved in DMSO (up to 8 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)