Thiazovivin, Rho kinase inhibitor; Induces fibroblast reprogrammng

Product Details

Formal Name: N-Benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide

Molecular Formula: C₁₅H₁₃N₅OS

Formula Weight: 311.40

CAS Number: 1226056-71-8

Purity: >98%

Formulation: powder

Solubility: Soluble in DMSO (up to 30 mg/ml).

Storage: -20°C

Stability: ≥ 2 years.

Applications

Rho kinase inhibitor; Induces fibroblast reprogrammng

Functions

A ROCK inhibitor. Dramatically improves (200-fold) the efficiency of induced pluripotent stem cell generation from human fibroblasts.  Induces direct conversion of porcine embryonic fibroblasts into adipocytes. Improves survival of single hESCs on matrigel-coated plates after enzymatic dissociation (more than 30-fold). Cell permeable.

Application Procedures

First dissolved in DMSO (up to 30 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.

Research use only.

Documents

• Datasheet (PDF)
• MSDS (PDF)