Solubility: Soluble in DMSO (up to 10 mg/ml with warming)
Storage: Room temperature
Stability: ≥ 2 years.
Applications
Aquaporin 4 blocker
Functions
Aquaporin 4 channel blocker, IC50 = 3.1 μM. Reduces ischemic cerebral edema in a mouse model of focal cerebral ischemia using MRI. Increases regional cerebral blood flow as determined in wild-type and AQP-4 knockout mice. Reduces brain edema when administered after onset of ischemia in rat models.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml with warming), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
