Solubility: Soluble in DMSO (up to 10 mg/ml, warm)
Storage: -20°C
Stability: ≥ 2 years.
Applications
SIRT1 and 2 inhibitor
Functions
Activates p53 via inhibition of SIRT1 and SIRT2. Induces apoptosis in a variety of cancer cell lines including cutaneous T-cell lymphoma and melanoma among others. Induces cellular senescence in cultured rat primary astrocytes as well as other cell types.
Application Procedures
First dissolved in DMSO (up to 10 mg/ml, warm), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 3 months.
