Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml).
Storage: -20°C
Stability: ≥ 1 year.
Applications
AP-1 transcription factor inhibitor
Functions
Diterpenoid naphthoquinone found in Salvia sp. and isolated as an active component of the traditional Chinese medicine Tanshen. Tanshinone IIA displays anti-inflammatory activity and induces apoptosis in a variety of cell lines. Also inhibits AP-1 activity by suppressing jun-fos-DNA complex formation (IC50 = 0.22 µM).
Application Procedures
First dissolved in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml), then diluted to aqueous buffer. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
