Product Details
Formal Name: (2)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
Alternate Names: ICI-46474
Molecular Formula: C26H29NO ∙ C6H8O7
Formula Weight: 563.65
CAS Number: 54965-24-1
Purity: >98%
Formulation: powder
Solubility: Soluble in DMSO (up to 50 mg/ml).
Storage: RT
Stability: ≥ 1 year.
Applications
Estrogen receptor antagonist; GPR30 agonist
Functions
Estrogen receptor antagonist/partial agonist. Induces oxidative stress and apoptosis in estrogen receptor-negative cancer cell lines. Displays neuroprotective effects in permanent focal ischemia. Inhibits PKC. Potent agonist at GPR30 (membrane estrogen receptor). Clinically useful breast cancer agent.
Application Procedures
First dissolved in DMSO (up to 50 mg/ml), then diluted to aqueous buffer. Solutions in DMSO may be stored at -20°C for up to 2 months.
Research use only.
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